A MicroRNA Signature in Acute Coronary Syndrome Patients and Modulation by Colchicine.

Jennifer Y BarracloughMugdha V JoglekarAndrzej S JanuszewskiGonzalo MartínezDavid S CelermajerAnthony C KeechAnandwardhan A HardikarSanjay Patel

Published in: Journal of cardiovascular pharmacology and therapeutics (2020)

The levels of specific miRNAs elevated in ACS returned to levels similar to control individuals following colchicine. These miRNAs may mediate ACS (via inflammatory pathways) or increase post-ACS risk, and could be potentially used as biomarkers of treatment efficacy.

Keyphrases

acute coronary syndrome
percutaneous coronary intervention
antiplatelet therapy
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
oxidative stress
patient reported outcomes
replacement therapy
combination therapy
breast cancer risk