Transcriptional profiling and physiological roles of Aedes aegypti spermathecal-related genes.

Tales Vicari PasciniMarcelo Ramalho-OrtigãoJosé Marcos RibeiroMarcelo Jacobs-LorenaGustavo Ferreira Martins

Published in: BMC genomics (2020)

This study identified spermatheca-specific transcripts associated with sperm storage in Ae. aegypti. Using RNAi we characterized the role of eight spermathecal transcripts on various aspects of female fecundity and offspring survival. RNAi-induced knockdown of transcript AeSigP-66,427, coding for a Na+/Ca2+ protein exchanger, specifically interfered with egg production and reduced sperm motility. Our results bring new insights into the molecular basis of sperm storage and identify potential targets for Ae. aegypti control.

Keyphrases

aedes aegypti
zika virus
dengue virus
gene expression
diabetic rats
high fat diet
transcription factor
single cell
amino acid
drug induced
protein protein
oxidative stress
binding protein
human health
small molecule
insulin resistance
heat stress