Mathematical Prostate Cancer Evolution: Effect of Immunotherapy Based on Controlled Vaccination Strategy.
Dorota Ba DziulPaweł JakubczykLevan ChotorlishviliZaza ToklikishvilieJulian TraciakJoanna Jakubowicz-GilSylwia Chmiel-SzajnerPublished in: Computational and mathematical methods in medicine (2020)
Basic immunology research over several decades has led to an improved understanding of tumour recognition by components of the immune system and mechanism of tumour evasion from immune detection. These findings have ultimately led to creating antitumour immunotherapies in patients with different kind of cancer including prostate cancer. The increasing number of reports confirms that immune-based therapies have clinical benefit in patients with prostate cancer with potentially less toxicity in comparison with traditional systemic treatments including surgical resection, chemotherapy, or radiotherapy in various forms. This review focuses on the possibility of modulation of the optimal immunotherapy based on vaccination strategy adopted to individual patients in order to increase quality and quantity of their life.
Keyphrases
- prostate cancer
- radical prostatectomy
- end stage renal disease
- ejection fraction
- locally advanced
- newly diagnosed
- chronic kidney disease
- early stage
- peritoneal dialysis
- radiation therapy
- prognostic factors
- oxidative stress
- papillary thyroid
- quality improvement
- radiation induced
- young adults
- patient reported
- patient reported outcomes
- loop mediated isothermal amplification
- rectal cancer
- chemotherapy induced