Exposure to silicates and systemic autoimmune-related outcomes in rodents: a systematic review.

Lisa M F JanssenManosij GhoshFrauke LemaireK Michael PollardPeter H M Hoet

Published in: Particle and fibre toxicology (2022)

Parallels were observed between the findings from the animal (this review) and human (epidemiological) studies, arguing that experimental animal models are valuable tools for examining exacerbation or development of autoimmune disease after silicate exposure. However, genetic background and synergism between exposures should be considered in future studies.

Keyphrases

multiple sclerosis
endothelial cells
case control
drug induced
chronic obstructive pulmonary disease
air pollution
induced pluripotent stem cells
gene expression
copy number
skeletal muscle
weight loss
mechanical ventilation
respiratory failure