Downregulation of Lysosome-Associated Membrane Protein-2A Contributes to the Pathogenesis of COPD.

Yun-Jeong JeongKyoung-Hee LeeJisu WooJi Yeon KimChang Hoon Lee Chul Gyu Yoo

Published in: International journal of chronic obstructive pulmonary disease (2023)

Cigarette smoke-induced down-regulation of LAMP-2A is involved in acceleration of aging and apoptosis of lung epithelial cells, which might at least partially contribute to COPD pathogenesis.

Keyphrases

chronic obstructive pulmonary disease
lung function
oxidative stress
diabetic rats
high glucose
endoplasmic reticulum stress
cell proliferation
signaling pathway
cell death
drug induced
loop mediated isothermal amplification
sensitive detection