Cognitive function in primary and secondary progressive multiple sclerosis: a multiparametric MRI study.

Damiano MistriLaura CacciaguerraPaola ValsasinaElisabetta PaganiMassimo Filippi Maria Assunta Rocca

Published in: European journal of neurology (2023)

PPMS and SPMS had similar neuropsychological performance. Cognitive dysfunction in PPMS and SPMS was related to distinct patterns of structural MRI abnormalities and involvement of different white matter tracts, while RS FC alterations did not contribute to explain their global cognitive functioning.

Keyphrases

multiple sclerosis
white matter
contrast enhanced
magnetic resonance imaging
diffusion weighted imaging
mild cognitive impairment
computed tomography