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Differential gene expression response of synovial fibroblasts from temporomandibular joints and knee joints to dynamic tensile stress.

Ute NazetPatrick NeubertValentin SchatzSusanne GrässelPeter ProffJonathan JantschAgnes SchröderChristian Kirschneck
Published in: Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie (2021)
Osteoarthritis-related ECM remodelling markers experience almost no changes in strain-induced gene expression, whereas inflammation and bone remodelling processes seem to differ depending on synovial fibroblast origin. Our data indicate that risk factors for the development and progression of osteoarthritis such as mechanical overuse have a different pathological impact in the TMJ compared to the knee joint.
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