Differential gene expression response of synovial fibroblasts from temporomandibular joints and knee joints to dynamic tensile stress.
Ute NazetPatrick NeubertValentin SchatzSusanne GrässelPeter ProffJonathan JantschAgnes SchröderChristian KirschneckPublished in: Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie (2021)
Osteoarthritis-related ECM remodelling markers experience almost no changes in strain-induced gene expression, whereas inflammation and bone remodelling processes seem to differ depending on synovial fibroblast origin. Our data indicate that risk factors for the development and progression of osteoarthritis such as mechanical overuse have a different pathological impact in the TMJ compared to the knee joint.
Keyphrases
- gene expression
- knee osteoarthritis
- dna methylation
- rheumatoid arthritis
- oxidative stress
- total knee arthroplasty
- extracellular matrix
- diabetic rats
- high glucose
- bone mineral density
- electronic health record
- drug induced
- machine learning
- soft tissue
- stress induced
- bone loss
- postmenopausal women
- deep learning
- anterior cruciate ligament reconstruction
- anterior cruciate ligament
- bone regeneration