GOT2 Silencing Promotes Reprogramming of Glutamine Metabolism and Sensitizes Hepatocellular Carcinoma to Glutaminase Inhibitors.

Yunzheng LiBinghua LiYanchao XuLiyuan QianTiancheng XuGang MengHuan LiYe WangLaizhu ZhangXiang JiangQi LiuYuanyuan XieChunxiao ChengBeicheng SunDecai Yu

Published in: Cancer research (2022)

Altered glutamine metabolism induced by GOT2 loss supports HCC growth and metastasis but confers a targetable vulnerability to glutaminase inhibitors.

Keyphrases

climate change
induced apoptosis
oxidative stress
endoplasmic reticulum stress