Landscape of TPMT and NUDT15 Pharmacogenetic Variation in a Cohort of Canadian Pediatric Inflammatory Bowel Disease Patients.
April M KennedyAnne M GriffithsAleixo M MuiseThomas D WaltersAmanda RicciutoHien Quoc HuynhEytan WineKevan JacobsonSally LawrenceNicholas CarmanDavid R MackJennifer C deBruynAnthony R OtleyColette DeslandresWael El-MataryMary ZachosEric I BenchimolJeffrey CritchRilla SchneiderEileen CrowleyMichael LiNeil WarnerDermot P B McGovernDalin LiTalin HarituniansSarah RudinIris CohnPublished in: Inflammatory bowel diseases (2024)
These findings demonstrate the considerable interpopulation variability in PGx variation underlying thiopurine metabolism, which should be factored into testing diverse patient populations.