Knockdown of best1 Gene in Zebrafish Caused Abnormal Neuronal and Skeletal Development - A Subtype of Craniovertebral Junction Malformation?

Zhenlei LiuKang LiKai WangLei ZhangShanhang JiaHe WangFengzeng JianHao Wu

Published in: Neurospine (2024)

Best1 gene plays critical roles in ophthalmologic, neurological and skeletal development in zebrafish. A patient with a premature stop codon in BEST1 gene exhibited similar phenotypes, implying a subtype of CVJ malformation.

Keyphrases

genome wide
copy number
genome wide identification
case report
gene expression
cerebral ischemia
transcription factor
brain injury