Distinct DNA methylation targets by aging and chronic inflammation: a pilot study using gastric mucosa infected with Helicobacter pylori.

Satoshi YamashitaSohachi NanjoEmil RehnbergNaoko IidaHideyuki TakeshimaTakayuki AndoTakao MaekitaToshiro SugiyamaToshikazu Ushijima

Published in: Clinical epigenetics (2019)

Methylation by inflammation was not simple acceleration of age-related methylation. Targets of aberrant DNA methylation were different between young and old gastric mucosae, and driver genes were preferentially methylated in young gastric mucosa.

Keyphrases

dna methylation
helicobacter pylori
genome wide
oxidative stress
gene expression
helicobacter pylori infection
middle aged
copy number
transcription factor