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The Fetal Type of Posterior Cerebral Artery.

Ana-Maria DavidoiuDragoş Ionuţ MincăMugurel Constantin RusuSorin HostiucCorneliu Toader
Published in: Medicina (Kaunas, Lithuania) (2023)
Background and Objectives : Anatomical variations of the arterial circle of Willis (cW) are common. A posterior cerebral artery (PCA) fed mostly or exclusively from the internal carotid artery is a fetal PCA (FPCA), partial (p-FPCA), or full/complete (f-FPCA), respectively. Because FPCA occurs in different anatomical configurations of the cW sides, we aimed to document in detail these morphological possibilities of FPCA within the cW. Materials and Methods : FPCAs were documented on a retrospective set of 139 computed tomography angiograms. Results : FPCAs were found in thirteen cases, nine males and four females. In 7/13 cases there were two modified sides of the cW. In 5/13 cases there were three altered sides of the cW. Another case with FPCA showed four altered sides of the cW. In 10/13 cases, FPCA was unilateral and in the other three cases it was bilateral. Compared to the overall group, unilateral p-FPCAs were found in 1.43%, while unilateral f-FPCAs were found in 5.75%. A bilateral p-FPCA-f-FPCA combination was found in 0.71% and a bilateral f-FPCA-f-FPCA combination occurred in 1.43%. An anatomically isolated ICA was found in just one case with bilateral f-FPCA (0.71%). In 7/13 FPCA cases there were arterial variants exclusively in the posterior cW. In the other 6/13 FPCA cases, there were variants in both anterior and posterior circulation. There were no statistically significant associations of FPCA with sex or age. The higher prevalence of right-sided FPCA was not statistically significant. Conclusions : Anatomical assessments of cW should be performed on a case-by-case basis, as they may correspond to different cW morphologies.
Keyphrases
  • internal carotid artery
  • computed tomography
  • magnetic resonance imaging
  • copy number
  • gene expression
  • dna methylation
  • risk factors
  • blood brain barrier
  • genome wide
  • brain injury
  • cerebral ischemia