p53 Acetylation Exerts Critical Roles in Pressure Overload-Induced Coronary Microvascular Dysfunction and Heart Failure in Mice.
Xiaochen HeAubrey C CantrellQuinesha A WilliamsWei GuYingjie ChenJian-Xiong ChenHeng ZengPublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
Our data reveal the importance of p53 acetylation in coronary microvascular function, cardiac function, and remodeling and may provide a promising approach to improve hypertension-induced CMD and to prevent the transition of cardiac hypertrophy to HF.
Keyphrases
- heart failure
- high glucose
- coronary artery disease
- coronary artery
- diabetic rats
- blood pressure
- oxidative stress
- drug induced
- type diabetes
- left ventricular
- endothelial cells
- genome wide
- gene expression
- acute heart failure
- metabolic syndrome
- single cell
- big data
- skeletal muscle
- atrial fibrillation
- high fat diet induced
- dna methylation
- deep learning
- aortic valve