Association of high-affinity autoantibodies with type 1 diabetes high-risk HLA haplotypes.

Taylor M Triolo Laura L PyleHali BroncuciaTaylor ArmstrongLiping YuPeter A GottliebAndrea K Steck

Published in: The Journal of clinical endocrinology and metabolism (2021)

ECL-GADA positivity is associated with the HLA-DR3 and HLA-DR4 haplotypes and levels are associated with the HLA-DR3 haplotype. ECL-IAA positivity is associated with HLA-DR4 haplotype. These studies further contribute to the understanding of genetic risk and islet autoimmunity endotypes in type 1 diabetes.

Keyphrases

type diabetes
editorial comment
systemic lupus erythematosus
metabolic syndrome
gene expression
genome wide
copy number