A Subpopulation of Luminal Progenitors Secretes Pleiotrophin to Promote Angiogenesis and Metastasis in Inflammatory Breast Cancer.

Mengmeng Zhang Kaiwen Zhou Zilin Wang Ting Liu Laura E Stevens Filipa C Lynce Wendy Y Chen Sui Peng Yubin Xie Duanyang Zhai Qianjun Chen Yawei Shi Huijuan Shi Zhongyu Yuan Xiaoping Li Juan Xu Zhenhai Cai Jian-Ping Guo Nan Shao Ying Lin

Published in: Cancer research (2024)

Nonmalignant luminal progenitor cells expressing pleiotrophin promote angiogenesis by activating NRP1 and induce a prometastatic tumor microenvironment in inflammatory breast cancer, providing potential therapeutic targets for this aggressive breast cancer subtype.

Keyphrases

endothelial cells
oxidative stress
vascular endothelial growth factor
signaling pathway
risk assessment
breast cancer risk