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A Subpopulation of Luminal Progenitors Secretes Pleiotrophin to Promote Angiogenesis and Metastasis in Inflammatory Breast Cancer.

Mengmeng ZhangKaiwen ZhouZilin WangTing LiuLaura E StevensFilipa C LynceWendy Y ChenSui PengYubin XieDuanyang ZhaiQianjun ChenYawei ShiHuijuan ShiZhongyu YuanXiaoping LiJuan XuZhenhai CaiJian-Ping GuoNan ShaoYing Lin
Published in: Cancer research (2024)
Nonmalignant luminal progenitor cells expressing pleiotrophin promote angiogenesis by activating NRP1 and induce a prometastatic tumor microenvironment in inflammatory breast cancer, providing potential therapeutic targets for this aggressive breast cancer subtype.
Keyphrases
  • endothelial cells
  • oxidative stress
  • vascular endothelial growth factor
  • signaling pathway
  • risk assessment
  • breast cancer risk