Effect of Simvastatin Use in Free Tissue Transfer: An Experimental Study in a Rat Epigastric Free Flap Model.

Usama AbdelfattahTarek ElbanobyEun Na KimEun Jung ParkHyunsuk Peter SuhJoon Pio Jp Hong

Published in: Journal of reconstructive microsurgery (2020)

Simvastatin significantly improves the free flap survival by effective anti-inflammatory, vasodilator, and anticoagulant activities. Combined therapy did not have an antagonistic effect and further study is needed to see synergistic action through different mechanisms.

Keyphrases

anti inflammatory
venous thromboembolism
atrial fibrillation
cancer therapy
mesenchymal stem cells
bone marrow
free survival
drug delivery
cell therapy
smoking cessation