The effect of AUT00206, a Kv3 potassium channel modulator, on dopamine synthesis capacity and the reliability of [¹⁸F]-FDOPA imaging in schizophrenia.

The relationship between reduction in DA synthesis capacity and improvement in symptoms in the AUT00206 group provides evidence for a pharmacodynamic effect of the Kv3 channel modulator. The lack of a significant overall reduction in DA synthesis capacity in the AUT00206 group could be due to variability and the low number of subjects in this study. These findings support further investigation of Kv3 channel modulators for schizophrenia treatment. [¹⁸F]-FDOPA PET imaging showed very good test-retest reliability in patients with schizophrenia.