Galectin-1 promotes hepatocellular carcinoma and the combined therapeutic effect of OTX008 galectin-1 inhibitor and sorafenib in tumor cells.
Zoe LeungFrankie Chi Fat KoSze Keong TeyErnest Man Lok KwongXiaowen MaoBonnie Hei Man LiuAngel Po Yee MaYi Man Eva FungChi-Ming CheDanny Ka Ho WongChing Lung LaiIrene Oi-Lin NgJudy Wai Ping YamPublished in: Journal of experimental & clinical cancer research : CR (2019)
Gal-1 overexpression was detected in HCC and this played a role in promoting tumorigenic processes and metastasis. The function of Gal-1 was found to be mediated through RER1. The correlations between miR-22, Gal-1 and RER1 expressions demonstrated the importance of miR-22 regulation on Gal-1/RER1 oncogenic activity. Lastly, the combinational treatment of OTX008 and sorafenib proved to be an improved therapeutic option compared to when administering sorafenib alone.