Longitudinal patterns and predictors of response to standard-of-care therapy in lupus nephritis: data from the Accelerating Medicines Partnership Lupus Network.
Peter M IzmirlyMimi Y KimPhilip M CarlucciKatherine PreisingerBrooke Z CohenKristina DeonaraineDevyn ZaminskiMaria Dall'EraKenneth KalunianAndrea FavaH Michael BelmontMing WuChaim PuttermanJennifer AnolikJennifer L BarnasBetty DiamondAnne DavidsonDavid WofsyDiane KamenJudith A JamesJoel M GuthridgeWilliam ApruzzeseDeepak A RaoMichael H Weismannull nullMichelle PetriJill BuyonRichard FuriePublished in: Arthritis research & therapy (2024)
CR and PR rates at week 52 were consistent with the standard-of-care response rates observed in prospective registrational LN trials. Low sustained response rates underscore the need for more efficacious therapies and highlight how critically important it is to understand the molecular pathways associated with response and non-response.