Identification of Genetic Variants in Progressive Supranuclear Palsy in Southeast Asia.

Adeline Su Lyn Ng Ai-Huey Tan Yi Jayne Tan Jia Lun Lim Michelle Mulan Lian Alfand Marl Dy Closas Azlina Ahmad Annuar Viswanathan Shanthi Yuen Kang Chia Jia-Nee Foo Weng Khong Lim Eng-King Tan Shen-Yang Lim

Published in: Movement disorders : official journal of the Movement Disorder Society (2024)

The genetic findings in our PSP cohorts appear to be somewhat distinct from those in Western populations, and also suggest an overlap of the genetic architecture between PSP and other neurodegenerative diseases. Further functional studies and validation in independent Asian cohorts will be useful for improving our understanding of PSP genetics and guiding genetic screening strategies in these populations. © 2024 International Parkinson and Movement Disorder Society.

Keyphrases

genome wide
copy number
south africa
dna methylation
gene expression
genetic diversity