Identification of novel early pancreatic cancer biomarkers KIF5B and SFRP2 from "first contact" interactions in the tumor microenvironment.
Harrys Kishore Charles JacobRossana SignorelliJohn Lalith Charles RichardTyler KashuvShweta LavaniaAshley MiddletonBeatriz Aguilar GomezAnthony FerrantellaHaleh AmirianJunyi TaoAyse Burcu ErgonulMelinda Minucci BooneMarco HadisuryaWeiguo Andy TaoAnton IliukManoj Kumar KashyapMonica Garcia-BuitragoRajinder DawraAshok Kumar SalujaPublished in: Journal of experimental & clinical cancer research : CR (2022)
Proteomic characterization of EVs derived from mimicking conditions of epithelial and stromal cells in the tumor-microenvironment resulted in the identification of several proteins, some for the first time in EVs. These secreted EVs cannot induce changes in distant organ metastases in in vivo models of EV education, but modulate changes in the early murine microbiome. Among all the proteins that were analyzed (MMP3, KIF5B, SFRP2, and LOXL2), KIF5B and SFRP2 show promise as bona fide early pancreatic cancer biomarkers expressed in progressive stages of pancreatic cancer.