Acquisition of cancer stem cell properties in osteosarcoma cells by defined factors.

Shuichi FujiwaraTeruya KawamotoYohei KawakamiYasufumi KoterazawaHitomi HaraToshiyuki TakemoriKazumichi KitayamaShunsuke YahiroKenichiro KakutaniTomoyuki MatsumotoTakehiko MatsushitaTakahiro NiikuraMichiyo Koyanagi-AoiTakashi AoiRyosuke KurodaToshihiro Akisue

Published in: Stem cell research & therapy (2020)

In this study, we successfully generated OS CSC-like cells with significantly enhanced CSC properties following transduction of defined factors.

Keyphrases

cancer stem cells
induced apoptosis
cell cycle arrest
cell death
signaling pathway
oxidative stress