Versatility of targeted antibiotic-loaded gold nanoconstructs for the treatment of biofilm-associated bacterial infections.
Daniel G MeekerTengjiao WangWalter N HarringtonVladimir P ZharovSarah A JohnsonSamir V JenkinsStephanie E OyiboChristopher M WalkerWeston B MillsMark E ShirtliffKaren E BeenkenJingyi ChenMark S SmeltzerPublished in: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group (2019)
These results confirm the therapeutic versatility of our approach. However, to the extent that its synergistic efficacy is dependent on the ability to achieve both a lethal photothermal effect and the thermally controlled release of a sufficient amount of antibiotic, they also demonstrate the importance of carefully designing appropriate antibody and antibiotic combinations to achieve the desired therapeutic synergy.