Buformin alleviates sepsis-induced acute lung injury via inhibiting NLRP3-mediated pyroptosis through an AMPK-dependent pathway.

Bohao LiuZhong WangRuyuan HeRui XiongGuorui LiLin ZhangTinglv FuChenyuan LiNing LiQing Geng

Published in: Clinical science (London, England : 1979) (2022)

Our study confirmed that BF inhibited NLRP3-mediated pyroptosis in sepsis-induced ALI by up-regulating autophagy and Nrf2 protein level through an AMPK-dependent pathway. This provides a new strategy for clinical mitigation of sepsis-induced ALI.

Keyphrases

high glucose
diabetic rats
intensive care unit
acute kidney injury
oxidative stress
nlrp inflammasome
skeletal muscle
drug induced
cell death
small molecule
lps induced
protein kinase
amino acid