Hypothalamic OXT (Oxytocin) Neuron Activation Attenuates Intermittent Hypoxia-Induced Hypertension and Cardiac Dysfunction in an Animal Model of Sleep Apnea.
Jeannette RodriguezJoan B EscobarEmily Catherine CheungGrant KowalikRebekah RussoJhansi DyavanapalliBridget R AlberGrey HarralAman GillMakeda MelkieVivek JainKathryn Jaques SchunkeDavid MendelowitzMatthew Wyatt KayPublished in: Hypertension (Dallas, Tex. : 1979) (2023)
In animals already presenting with CIH-induced hypertension, chronic activation of hypothalamic OXT neurons blunted the progression of hypertension and conferred cardioprotection after an additional 4 weeks of CIH exposure. These results have significant clinical translation for the treatment of cardiovascular disease in patients with obstructive sleep apnea.
Keyphrases
- blood pressure
- sleep apnea
- obstructive sleep apnea
- cardiovascular disease
- positive airway pressure
- oxidative stress
- spinal cord
- type diabetes
- drug induced
- diabetic rats
- left ventricular
- high glucose
- case report
- arterial hypertension
- cardiovascular events
- cardiovascular risk factors
- metabolic syndrome
- endothelial cells
- gestational age