Antagonizing EZH2 combined with vitamin D3 exerts a synergistic role in anti-fibrosis through bidirectional effects on hepatocytes and hepatic stellate cells.

Qinghui ZhangRongrong JiaMinjie ChenJianjun WangFeng HuangMin ShiHuiming ShengLing Xu

Published in: Journal of gastroenterology and hepatology (2023)

Vitamin D3 is responsible for the anti-fibrosis, which might have bidirectional effects on HSCs by regulating histone modification. The inhibitor of Ezh2 plays a synergistic role in this process.

Keyphrases

induced apoptosis
long non coding rna
cancer therapy
long noncoding rna
cell cycle arrest
gene expression
signaling pathway
liver injury
drug delivery
drug induced
pi k akt