Whole transcriptional analysis identifies markers of B, T and plasma cell signaling pathways in the mesenteric adipose tissue associated with Crohn's disease.

Francesca Aparecida Ramos da SilvaLívia Bitencourt PascoalIsabella DottiMaria de Lourdes Setsuko AyrizonoDaniel AguilarBruno Lima RodriguesMontserrat ArroyesElena Ferrer-PiconMarciane MilanskiLício Augusto VellosoJoão José FagundesAzucena SalasRaquel Franco Leal

Published in: Journal of translational medicine (2020)

Our data strongly supports the role of CD-associated MAT as a site for T-, B- and plasma cell activation, and suggests that it could also act as a reservoir of memory immune responses.

Keyphrases

adipose tissue
immune response
single cell
cell therapy
signaling pathway
gene expression
electronic health record
genome wide
working memory
cell proliferation
metabolic syndrome
pi k akt
inflammatory response
data analysis
induced apoptosis
water quality