Deep sequencing of human papillomavirus positive loco-regionally advanced oropharyngeal squamous cell carcinomas reveals novel mutational signature.

Christian Grønhøj LarsenDavid H JensenTina AganderKatalin KissEstrid HøgdallLena SpechtFrederik Otzen BaggerFinn Cilius NielsenChristian von Buchwald

Published in: BMC cancer (2018)

We have identified multiple genetic aberrations in HPV+ OPSCCs, and the COSMIC signature 12 as most prevalent. The mutations harbour both therapeutic and prognostic potential.

Keyphrases

squamous cell
high grade
copy number
genome wide
risk assessment
human health
dna methylation
climate change