Cognitive decline in Huntington's disease in the Digitalized Arithmetic Task (DAT).

Marine LunvenJennifer Hamet BagnouKatia YoussovAlexis GabadinhoRafika FlissJustine MontillotEtienne AudureauBlanche BapstGraça MorgadoRalf ReilmannRobin SchubertMonica BusseDavid CraufurdRenaud MassartAnne E RosserAnne-Catherine Bachoud-Lévi

Published in: PloS one (2021)

DAT is fast, reliable, motor-free, applicable in several languages, and able to unmask cognitive decline correlated with striatal atrophy in small cohorts of HD patients. This likely makes it a useful endpoint in future trials for HD and other neurodegenerative diseases.

Keyphrases

cognitive decline
mild cognitive impairment
end stage renal disease
newly diagnosed
ejection fraction
peritoneal dialysis
prognostic factors
parkinson disease
patient reported outcomes
patient reported