Invasive growth of brain metastases is linked to CHI3L1 release from pSTAT3-positive astrocytes.
Matthew DanknerSarah M MaritanNeibla PriegoGeorgia KruckAndriniaina Nkili-MeyongJavad NadafRebecca ZhuangMatthew G AnnisDongmei ZuoAlexander NowakowskiMarco BiondiniAlexander KiepasCaitlyn MourcosPhuong LeFrançois CharronYanis InglebertPaul SavageLouis ThéretMarie-Christine GuiotR Anne McKinneyWilliam J MullerMorag ParkManuel ValienteKevin PetreccaPeter M SiegelPublished in: Neuro-oncology (2024)
Together, these data reveal that pSTAT3+ RA-derived CHI3L1 is associated with BrM invasion, implicating STAT3 and CHI3L1 as clinically relevant therapeutic targets for the treatment of HI BrM.
Keyphrases
- brain metastases
- small cell lung cancer
- rheumatoid arthritis
- cell proliferation
- electronic health record
- genome wide
- cell migration
- single cell
- gene expression
- systemic lupus erythematosus
- combination therapy
- systemic sclerosis
- replacement therapy
- artificial intelligence
- idiopathic pulmonary fibrosis
- interstitial lung disease
- smoking cessation