Molecular mechanisms in chloroquine-exposed muscle cells elucidated by combined proteomic and microscopic studies.

Vietxuan PhanDenisa HathaziAndreas RoosArtur CzechErik FreierGerta ShemaRené ZahediAndreas Roos

Published in: Neuropathology and applied neurobiology (2023)

We demonstrated that CQ exposure (secondarily) impacts biological processes beyond lysosomal function and linked a variety of proteins with known roles in the manifestation of other neuromuscular diseases.

Keyphrases

induced apoptosis
cell cycle arrest
skeletal muscle
endoplasmic reticulum stress
cell death
signaling pathway
cell proliferation