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Phenylpropanoid-conjugated iridoid glucosides from leaves of Morinda morindoides.

Yasinjan HashimKazufumi ToumeShusaku MizukamiToshinori KitamiMayumi TaniguchiAwet Alem TeklemichaelYuki TayamaNguyen Tien HuyJosé Nzunzu LamiJoseph M BodiKenji HirayamaKatsuko Komatsu
Published in: Journal of natural medicines (2021)
Three phenylpropanoid-conjugated iridoid glucosides, acetylgaertneric acid (1), acetyldehydrogaertneroside (2), and dehydrogaertneric acid (10), together with nine known related iridoid glucosides (3-9, 11, and 12), two coumaroyl alkaloids, one benzenoid, and three flavonoid glucosides were isolated from leaves of Morinda morindoides (Rubiaceae). Structures of these isolated compounds were determined using spectroscopic analysis. Compounds 1-18 and previously isolated compounds (19-29) were evaluated for anti-trypanosomal activity against Trypanosoma cruzi Tulahuen strain (trypomastigote and amastigote) together with cytotoxicity against host cells, new-born mouse heart cells. Among them, molucidin (21) and prismatomerin (22) exhibited good anti-trypanosomal activity (IC50 of 4.67 and 5.70 µM, respectively), together with cytotoxicity (CC50 of 2.76 and 3.22 μM, respectively). Compounds 1-18 did not show anti-malarial activity against a chloroquine/mefloquine-sensitive strain of Plasmodium falciparum.
Keyphrases
  • plasmodium falciparum
  • induced apoptosis
  • cell cycle arrest
  • heart failure
  • molecular docking
  • high resolution
  • cell death
  • signaling pathway
  • oxidative stress
  • mass spectrometry
  • gestational age
  • drug induced
  • data analysis