A multiple genome analysis of Mycobacterium tuberculosis reveals specific novel genes and mutations associated with pyrazinamide resistance.

Patricia SheenDavid RequenaEduardo GushikenRobert H GilmanRicardo AntiparraBryan LuceroPilar LizárragaBasilio CiezaElisa RoncalLouis GrandjeanArnab PainRuth McNerneyTaane G ClarkDavid MooreMirko Zimic

Published in: BMC genomics (2017)

These results suggest potential alternate mechanisms of PZA resistance that have not been found in other populations, supporting that the antibacterial activity of PZA may hit multiple targets.

Keyphrases

mycobacterium tuberculosis
genome wide
pulmonary tuberculosis
gene expression
transcription factor
genome wide identification
genetic diversity
silver nanoparticles