Circular RNA detection identifies circPSEN1 alterations in brain specific to autosomal dominant Alzheimer's disease.

Hsiang-Han ChenAbdallah EteleebCiyang WangMaria Victoria FernandezJohn P BuddeKristy BergmannJoanne NortonFengxian WangCurtis EblJohn C MorrisRichard J PerrinRandall J BatemanEric McDadeChengjie XiongAlison GoateMartin FarlowJasmeer ChhatwalPeter R SchofieldHelena ChuiOscar HarariCarlos CruchagaIbanez Lauranull null

Published in: Acta neuropathologica communications (2022)

Our findings show the differential expression of circPSEN1 is increased in ADAD. Given the biological function previously ascribed to circular RNAs and the results of our in-silico analyses, we hypothesize that this finding might be related to neuroinflammatory events that lead or that are caused by the accumulation of amyloid-beta.

Keyphrases

genome wide
resting state
molecular docking
white matter
loop mediated isothermal amplification
cognitive decline
real time pcr
functional connectivity
cerebral ischemia
gene expression
dna methylation
mild cognitive impairment
blood brain barrier
drug induced
brain injury