Characterisation of ovine bone marrow-derived stromal cells (oBMSC) and evaluation of chondrogenically induced micro-pellets for cartilage tissue repair in vivo.

K FutregaE MusicP G RobeyS GronthosR CrawfordS SaifzadehT J KleinMichael Robert Doran

Published in: Stem cell research & therapy (2021)

The sensitivity of oBMSC, compared to human BMSC, to IBMX in standard adipogenic assays highlights species-associated differences. Micro-pellets manufactured from oACh were more effective than micro-pellets manufactured from oBMSC in the repair of osteochondral defects in sheep. While oBMSC can be driven to form cartilage-like tissue in vitro, the effective use of these cells in cartilage repair will depend on the successful mitigation of hypertrophy and tissue integration.

Keyphrases

endothelial cells
induced apoptosis
extracellular matrix
high glucose
climate change
oxidative stress
high throughput
drug induced
endoplasmic reticulum stress
induced pluripotent stem cells
cell death