A common signaling pathway leading to degranulation in mast cells and its regulation by CCR1-ligand.

Hyeun Wook ChangShiro KanegasakiFansi JinYifeng DengZhiwei YouJae-Hoon ChangDong Young KimMaheshwor TimilshinaJae-Ryong KimYoun Ju LeeNoriko Toyama-SorimachiTomoko Tsuchiya

Published in: Allergy (2020)

Linker for activation of T cells plays a central role in signal transduction pathways in mast cells stimulated with any ligand tested. Dose-dependent alternate costimulation and inhibition of CCR1 ligands in IgE/Ag-, SCF-, or HSP70-stimulated mast cells occur at the level of Lck-LAT phosphorylation.

Keyphrases

signaling pathway
dendritic cells
regulatory t cells
heat shock protein
pi k akt
heat shock
epithelial mesenchymal transition
heat stress
quantum dots
induced apoptosis
visible light
atopic dermatitis