Extracorporeal photopheresis: Is one ounce of blood enough? Case reports.
Kumukova IrinaKurnikova ElenaTrakhtman PavelPublished in: Pediatric blood & cancer (2023)
Extracorporeal photopheresis (ECP) has proven effective in the treatment of several diseases, including acute and chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation. In its standard version, ECP requires leukapheresis to obtain a fraction of mononuclear cells. The possibility of using leukapheresis is limited by the requirements for vascular access and the somatic status of the patient. We have developed a new ECP method that does not require leukapheresis. This paper presents a description of two clinical cases of severe refractory GVHD treated by micro-ECP.
Keyphrases
- allogeneic hematopoietic stem cell transplantation
- acute myeloid leukemia
- acute lymphoblastic leukemia
- case report
- induced apoptosis
- drug induced
- liver failure
- cell cycle arrest
- respiratory failure
- peripheral blood
- early onset
- oxidative stress
- endoplasmic reticulum stress
- cell death
- intensive care unit
- dna methylation
- acute respiratory distress syndrome