Cerebrovascular reactivity MRI as a biomarker for cerebral small vessel disease-related cognitive decline: Multi-site validation in the MarkVCID Consortium.
Peiying LiuZixuan LinKaisha HazelGeorge PottanatCuimei XuDengrong JiangJay J PillaiEmma LuckeChristopher E BauerBrian T GoldSteven M GreenbergKarl G HelmerKay JannGregory JichaJoel KramerPauline MaillardRachel M MulavelilPavel RodriguezClaudia L SatizabalKristin SchwabSudha SeshadriHerpreet SinghÁngel G Velarde DediósDanny J J WangRita R KalyaniAbhay MoghekarPaul B RosenbergSevil YasarMarilyn AlbertHanzhang LuPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
This study measured a novel functional index of small arteries referred to as cerebrovascular reactivity (CVR). CVR was positively associated with global cognition in older adults. This finding was observed in three independent cohorts at three sites. Our statistical analysis plan was predefined before beginning data collection.