Potential Transcriptional Biomarkers to Guide Glucocorticoid Replacement in Autoimmune Addison's Disease.

Åse Bjorvatn SævikAnette B WolffSigridur BjörnsdottirKaterina SimunkovaMartha Schei HynneDavid William Peter DolanEirik BratlandPer M KnappskogPaal MethlieSiri CarlsenMagnus IsakssonSophie Bensing Olle Kämpe Eystein Sverre HusebyeKristian LøvåsMarianne Øksnes

Published in: Journal of the Endocrine Society (2021)

We introduce gene expression as a novel approach to guide GC replacement in AAD. We suggest that gene expression of DSIPI, DDIT4, and FKBP5 are particularly promising candidate biomarkers of GC replacement, followed by MMP9, CEBPB, VDR, ADARB1, ARID5B, and POU2F1.

Keyphrases

gene expression
dna methylation
multiple sclerosis
gas chromatography
risk assessment
human health
oxidative stress
climate change
drug induced
heat shock protein
tandem mass spectrometry