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Glucuronidation and its effect on the bioactivity of amentoflavone, a biflavonoid from Ginkgo biloba leaves.

Lili GanJiating MaGuoquan YouJinxia MaiZhaoyu WangRuopeng YangCong XieJingrao FeiLan TangJie ZhaoZheng CaiLing Ye
Published in: The Journal of pharmacy and pharmacology (2020)
A low AMF bioavailability was due to extensive glucuronidation, which was mediated by UGT1A1 and UGT1A3. Glucuronidated AMF metabolites had the same antioxidant but had a lower anticancer activity than that of AMF.
Keyphrases
  • oxidative stress
  • ms ms
  • anti inflammatory