Enantioselective Syntheses of C2-Symmetric Pyrazolones and Diones via One-Pot Organo-/Iodine Sequential Catalysis.

Kai-Xiang FengCheng-Ke TangQiao-Yu ShenAi-Bao XiaLi-Sha HuangZhan-Yu ZhouXing ZhangXiao-Hua DuDan-Qian Xu

Published in: Organic letters (2021)

The catalytic diastereo- and enantioselective syntheses of C2-symmetric axially chiral 1,4-dicarbonyl derivatives with 2,3-quaternary stereocenters were achieved by utilizing an organo-/iodine binary catalytic strategy. The reactions proceeded well under mild conditions without metals or strong bases.

Keyphrases

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ionic liquid
crystal structure
human health
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