The tumour microenvironment shapes innate lymphoid cells in patients with hepatocellular carcinoma.

Bernd HeinrichE Michael GertzAlejandro A SchäfferAmanda CraigBenjamin RufVarun SubramanyamJohn C McVeyLaurence P DiggsSophia HeinrichUmberto RosatoChi MaChunhua YanYing HuYongmei ZhaoTsai-Wei ShenVeena KapoorWilliam TelfordDavid E KleinerMerril K StovroffHarmeet S DhaniJiman KangThomas FishbeinXin Wei WangE RuppinAlexander KroemerTim F GretenFirouzeh Korangy

Published in: Gut (2021)

Our results suggest that the tumour cytokine milieu controls ILC composition and HCC outcome. Specific changes of cytokines modify ILC composition in the tumour by inducing plasticity and alter ILC function.

Keyphrases

nk cells
induced apoptosis
stem cells
cell cycle arrest
cell death
signaling pathway
endoplasmic reticulum stress