Peritoneal macrophages have an impaired immune response in obesity which can be reversed by subsequent weight loss.
Lisa WillemsenAnnette E NeeleSaskia van der VeldenKoen H M PrangeMyrthe den ToomCindy P A A van RoomenMyrthe E ReicheGuillermo R GriffithMarion J J GijbelsEsther LutgensMenno P J de WintherPublished in: BMJ open diabetes research & care (2019)
In contrast to the proinflammatory phenotype of adipose tissue macrophages in obesity and T2D, we found a deactivated state of PMs in obesity and T2D. Weight loss could reverse this deactivated macrophage phenotype. Anti-inflammatory characteristics of these non-adipose macrophages may explain why patients with obesity and T2D have an impaired immune response against pathogens. Our data also suggest that losing weight restores macrophage function and thus contributes to the reduction of immune-related comorbidities in patients.
Keyphrases
- weight loss
- adipose tissue
- bariatric surgery
- insulin resistance
- immune response
- roux en y gastric bypass
- weight gain
- gastric bypass
- metabolic syndrome
- end stage renal disease
- high fat diet induced
- type diabetes
- anti inflammatory
- glycemic control
- chronic kidney disease
- obese patients
- peritoneal dialysis
- body mass index
- dendritic cells
- computed tomography
- physical activity
- prognostic factors
- magnetic resonance
- inflammatory response
- patient reported outcomes
- artificial intelligence