MicroRNAs Possibly Involved in the Development of Bone Metastasis in Clear-Cell Renal Cell Carcinoma.
Lisa KingetEduard RousselDiether LambrechtsBram BoeckxLoïc VanginderhuysenMaarten AlbersenCristina Rodríguez-AntonaOsvaldo Graña-CastroLucía Inglada-PérezAnnelies VerbiestJessica Zucman-RossiGabrielle CouchyStefano CarusoAnnouschka LaenenMarcella BaldewijnsBenoit BeuselinckPublished in: Cancers (2021)
Bone metastasis in clear-cell renal cell carcinoma (ccRCC) leads to substantial morbidity through skeletal related adverse events and implicates worse clinical outcomes. MicroRNAs (miRNA) are small non-protein coding RNA molecules with important regulatory functions in cancer development and metastasis. In this retrospective analysis we present dysregulated miRNA in ccRCC, which are associated with bone metastasis. In particular, miR-23a-3p, miR-27a-3p, miR-20a-5p, and miR-335-3p specifically correlated with the earlier appearance of bone metastasis, compared to metastasis in other organs. In contrast, miR-30b-3p and miR-139-3p were correlated with less occurrence of bone metastasis. These miRNAs are potential biomarkers and attractive targets for miRNA inhibitors or mimics, which could lead to novel therapeutic possibilities for bone targeted treatment in metastatic ccRCC.
Keyphrases
- bone mineral density
- soft tissue
- bone loss
- bone regeneration
- small cell lung cancer
- squamous cell carcinoma
- risk assessment
- magnetic resonance
- magnetic resonance imaging
- postmenopausal women
- computed tomography
- small molecule
- transcription factor
- papillary thyroid
- lymph node metastasis
- combination therapy
- replacement therapy
- smoking cessation