Correlation between CNS Tuberculosis and the COVID-19 Pandemic: The Neurological and Therapeutic Insights.
Narattam MandalNayan DePulak JanaAchinta SannigrahiKrishnananda ChattopadhyayPublished in: ACS chemical neuroscience (2020)
The recent outbreak of Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) from Wuhan, China, was caused by a single-stranded RNA virus which has kept the entire world stranded. The outbreak was first diagnosed with respiratory illness, but recent findings of acute necrotizing hemorrhage of brain, brain encephalopathy, and the presence of the virus in the cerebrospinal fluid (CSF) have unveiled its neuroinvasivness. Various clinical features related to the central nervous system (CNS) and peripheral nervous system (PNS) due to COVID-19 infection are now identified. We demonstrate here an apparent similarity in neurological disorders of COVID-19 with CNS tuberculosis, which suggests that some anti-tubercular drugs may be used as therapeutic agents against COVID-19 infection.
Keyphrases
- respiratory syndrome coronavirus
- sars cov
- cerebrospinal fluid
- coronavirus disease
- blood brain barrier
- cerebral ischemia
- mycobacterium tuberculosis
- resting state
- white matter
- binding protein
- liver failure
- pulmonary tuberculosis
- nucleic acid
- hiv aids
- drug induced
- functional connectivity
- respiratory failure
- emergency department
- early onset
- hepatitis c virus
- hepatitis b virus
- diffusion weighted imaging
- aortic dissection
- magnetic resonance imaging
- intensive care unit