Label-Free Assessment of Mannitol Accumulation Following Osmotic Blood-Brain Barrier Opening Using Chemical Exchange Saturation Transfer Magnetic Resonance Imaging.
Jing LiuChengyan ChuJia ZhangChongxue BieLin ChenSafiya AafreenJiadi XuDavid O KamsonPeter C M van ZijlPiotr WalczakMiroslaw JanowskiGuanshu LiuPublished in: Pharmaceutics (2022)
We demonstrated that CEST MRI can be used for non-invasive, label-free detection of mannitol accumulation in the brain following BBBO treatment. This method may be useful as a rapid imaging tool to optimize the dosing of mannitol-based OBBBO and improve its safety and efficacy.
Keyphrases
- label free
- blood brain barrier
- magnetic resonance imaging
- cerebral ischemia
- contrast enhanced
- high resolution
- computed tomography
- loop mediated isothermal amplification
- diffusion weighted imaging
- white matter
- resting state
- magnetic resonance
- combination therapy
- photodynamic therapy
- sensitive detection
- fluorescence imaging
- smoking cessation