Mineralocorticoid receptor antagonism prevents obesity-induced cerebral artery remodeling and reduces white matter injury in rats.
Paulo W PiresJonathon L McClainSebastian F HayozAnne M DorrancePublished in: Microcirculation (New York, N.Y. : 1994) (2018)
These data suggest that HF feeding leads to MR dependent remodeling of the MCA and this is associated with markers of dementia development.
Keyphrases
- white matter
- insulin resistance
- mild cognitive impairment
- metabolic syndrome
- high glucose
- diabetic rats
- type diabetes
- weight loss
- subarachnoid hemorrhage
- electronic health record
- cognitive impairment
- multiple sclerosis
- high fat diet induced
- weight gain
- magnetic resonance
- drug induced
- mouse model
- oxidative stress
- contrast enhanced
- machine learning
- adipose tissue
- cerebral ischemia
- computed tomography
- binding protein
- brain injury
- atrial fibrillation
- stress induced
- deep learning