Andrographolide enhances the anti-metastatic effect of radiation in Ras-transformed cells via suppression of ERK-mediated MMP-2 activity.

Chih-Chia YuChien-An ChenShu-Ling FuHon-Yi LinMoon-Sing LeeWen-Yen ChiouYu-Chieh SuShih-Kai Hung

Published in: PloS one (2018)

These findings suggest that andrographolide enhances the anti-metastatic effect of radiation in Ras-transformed cells via suppression of ERK-mediated MMP-2 activity.

Keyphrases

induced apoptosis
signaling pathway
squamous cell carcinoma
small cell lung cancer
cell cycle arrest
endoplasmic reticulum stress
oxidative stress
radiation therapy
radiation induced
wild type
cell migration