The Fire Within: NF-κB Involvement in Non-Small Cell Lung Cancer.
Foteinos-Ioannis D DimitrakopoulosAnastasia E KottorouMelpomeni KalofonouHaralabos P KalofonosPublished in: Cancer research (2020)
Thirty-four years since its discovery, NF-κB remains a transcription factor with great potential for cancer therapy. However, NF-κB-targeted therapies have yet to find a way to be clinically translatable. Here, we focus exclusively on the role of NF-κB in non-small cell lung cancer (NSCLC) and discuss its contributing effect on cancer hallmarks such as inflammation, proliferation, survival, apoptosis, angiogenesis, epithelial-mesenchymal transition, metastasis, stemness, metabolism, and therapy resistance. In addition, we present our current knowledge of the clinical significance of NF-κB and its involvement in the treatment of patients with NSCLC with chemotherapy, targeted therapies, and immunotherapy.
Keyphrases
- signaling pathway
- epithelial mesenchymal transition
- oxidative stress
- lps induced
- pi k akt
- nuclear factor
- small cell lung cancer
- transcription factor
- cancer therapy
- inflammatory response
- healthcare
- small molecule
- stem cells
- cell cycle arrest
- endothelial cells
- cell death
- transforming growth factor
- toll like receptor
- radiation therapy
- locally advanced
- cell proliferation
- high throughput
- squamous cell
- climate change
- wound healing
- cancer stem cells