Palladium-Catalyzed Carbonylation of Aryl Bromides with Carbon Dioxide To Access Aryl Carboxylic Acids under Mild Conditions.

A palladium-catalyzed direct carbonylation of aryl bromides with carbon dioxide as the carbonyl source has been developed by using Pd(dba) 2 /DPEPhos as the catalyst under mild reaction conditions, providing an efficient route to a variety of aryl carboxylic acids in moderate to high yields. The methods have many advantages such as the use of a simple palladium catalyst system, wide substrate scope, good functional group tolerance, high yields, and easy scalability.